Drug compound lowers blood pressure!
Published on May 7 2008
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Subject: Drug compound lowers blood pressure
GAINESVILLE, Fla., May 5 (UPI) -- U.S. scientists say
they've created a drug compound that lowers blood pressure and
prevents heart and kidney damage in rats with persistent
The University of Florida researchers said their findings
could lead to a new class of antihypertensive drugs designed to
address two major problems associated with cardiovascular disease:
high blood pressure and the tissue damage associated with it, known
"When people have heart attacks (or suffer from
hypertension) the blood vessels get more rigid," said Assistant
Professor David Ostrov. "We discovered a compound that reverses the
fibrosis that makes the blood vessels more rigid."
He said the discovery, in itself, is significant because no
one has ever specifically identified a compound that enhances the
activity of an enzyme -- in this case ACE2 -- using a rational
"In other words, no one has ever done this before on
purpose," he said. "People have discovered molecules that enhance
the activity of enzymes by trial and error but no group has ever
done it in a specifically pointed way like this."
Additional research, he said, will continue to explore the
compound's effectiveness in animals and humans.
The findings appear in the journal Hypertension.
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