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Fats in organs and blood increases the risk of Osteoporosis

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Fats in organs and blood increases the risk of Osteoporosis

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The study found that obese people with higher levels of fat in their liver, blood and muscle tissue also have higher amounts of fat in their bone marrow, and puts them at risk for osteoporosis.

20th July, 2013 USA (http://www.royalpharmacyrx.com/) : Surplus fat around the belly has recently been recognized as a risk factor for bone loss. A study has determined that excess liver and muscle fat also may be detrimental to bone. The study found that obese people with higher levels of fat in their liver, blood and muscle tissue also have higher amounts of fat in their bone marrow, and puts them at risk for osteoporosis.

Obesity was once thought to be protective against bone loss. In our study, we focused on bone marrow fat because that is where our stem cells can develop into osteoblasts - the cells responsible for bone formation - or fat cells.

They used proton magnetic resonance spectroscopy (MRS), a technique that allows for precise measurement of fat. MRS has no radiation, is quick to perform and can quantify the amount of fat within bone marrow, muscle and liver. The MRS results showed that people with more liver and muscle fat had higher levels of fat in their bone marrow, independent of age, exercise and body mass index status. HDL cholesterol, the "good" type of cholesterol that is associated with a lower risk of heart disease, was on contrary interrelated with bone marrow fat content.

Higher levels of bone marrow fat put people at increased risk of fracture. Bone marrow fat makes bones weak. Triglycerides, the type of fat found in the blood, also had a positive interrelation with bone marrow fat, possibly because they promote osteoclasts, a type of cell that breaks up bone tissue. Obesity can shift stem cell lineage, which resulted in more bone marrow fat.

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Fats in organs and blood increases the risk of Osteoporosis The study found that obese people with higher levels of fat in their liver, blood and muscle tissue also have higher amounts of fat in their bone marrow, and puts them at risk for osteoporosis.

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