Zyrop medication is an erythropoiesis-stimulating agent - onlinegenericpills

• Mar 19 2014, Los Angeles, (http://onlinegenericpills.com/) : Erythropoietin, also known as erythropoietin or erthropoyeti or EPO, is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine (protein signaling molecule) for erythrocyte (red blood cell) precursors in the bone marrow. Human EPO has a molecular weight of 34 kDa.

Also called hematopoietin or hemopoietin, it is produced by interstitial fibroblasts in the kidney in close association with peritubular capillary and tubular epithelial tubule. It is also produced in perisinusoidal cells in the liver. While liver production predominates in the fetal and perinatal period, renal production is predominant during adulthood. In addition to erythropoiesis, erythropoietin also has other known biological functions. For example, it plays an important role in the brain's response to neuronal injury. It is also involved in the wound healing process.

Function :

Erythropoietin is an essential hormone for red cell production. Without it, definitive erythropoiesis does not take place. Under hypoxic conditions, the kidney will produce and secrete erythropoietin to increase the production of red blood cells by targeting CFU-E, pro erythroblast and basophilic erythroblast subsets in the differentiation. Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in humans) by promoting their survival through protecting these cells from apoptosis.

Erythropoietin is the primary erythropoietic factor that cooperates with various other growth factors involved in the development of erythroid lineage from multi potent progenitors. The burst-forming unit-erythroid (BFU-E) cells start erythropoietin receptor expression and are sensitive to erythropoietin. Subsequent stage, the colony-forming unit-erythroid (CFU-E), expresses maximal erythropoietin receptor density and is completely dependent on erythropoietin for further differentiation. Precursors of red cells, the pro erythroblasts and basophilic erythroblasts also express erythropoietin receptor and are therefore affected by it.

Mechanism of action :

Erythropoietin has been shown to exert its effects by binding to the erythropoietin receptor (EpoR).

It is highly glycosylated (40% of total molecular weight), with half-life in blood around five hours. Its half-life may vary between endogenous and various recombinant versions. Additional glycosylation or other alterations of it via recombinant technology have led to the increase of EPO's stability in blood (thus requiring less frequent injections). EPO binds to the erythropoietin receptor on the red cell progenitor surface and activates a JAK2 signaling cascade.

Erythropoietin receptor expression is found in a number of tissues, such as bone marrow and peripheral/central nervous tissue. In the bloodstream, red cells themselves do not express erythropoietin receptor, so cannot respond to this drug. However, indirect dependence of red cell longevity in the blood on plasma erythropoietin levels has been reported, a process termed neocytolysis.

Storage :

Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

For more please visit :

Martin Adam http://onlinegenericpills.com/ Los Angeles, CA, USA martinadam0122@gmail.com

Hi everyone, this is Martin Adam from USA. I am completed P.HD in pharmacy. I do lots of work in pharmacy but now I am working in Onlinegenericpills.com. I also write blog on all health related product like Penegra, Mifeprex, Xenical, Zyrop price online, Gabapentin, Lyrica, etc.