Risk of fungal disease increase in HIV-infected patients with certain links

20th September, 2013 (http://www.kamagrasex.com) - According to a new study, the researchers revealed that HIV-infected people carry a gene for a specific protein face a 20-fold greater risk of contracting cryptococcal disease. Cryptococcus neoformans is the most common cause of fungal meningitis among HIV-infected individuals. The disease is a risk for everyone with HIV who has a very low level of CD4+ T cells.

The researchers have discovered that those with the gene for the protein FCGR3A 158V have an immune cell receptor that binds tightly to antibody-bound C. neoformans. On contrary, this tight binding by a vigilant immune system may mean the patient's own immune system strength becomes a weakness when facing the fungus.

They also found that this high affinity Fc receptor polymorphism was very highly overrepresented in the patients that got cryptococcal disease. Patients with two copies of the high affinity Fc receptor gene had an almost 20-fold increased risk of contracting the disease.

Differences among Fc gamma receptors (FCGR) have already been linked to cryptococcosis susceptibility among people who are not infected with HIV, but this new information focuses on how these receptors could influence susceptibility in HIV patients, who are at a high risk of developing cryptococcosis and are known to have high levels of antibodies.

FCGRs are proteins expressed on the outsides of different kinds of immune cells, embracing B lymphocytes, macrophages, natural killer cells, neutrophils, and mast cells. They fasten to antibodies that have grabbed onto attacking pathogens, and then encourage the immune cells to demolish the invaders.

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John Anderson completed his graduation in Biotechnology and also did PhD in Bio-pharmacology. He works as a medical consultant for kamagrasex.com