Dostinex is a type of medicine called a dopamine agonist - onlinegenericpills

• Apr 09 2014, Vittel, (http://onlinegenericpills.com/) : Dostinex has been approved for the treatment of hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas (tumors).

Indications :

 hyperprolactinemia

 adjunctive therapy of prolactin-producing pituitary gland tumors (prolactinomas);

 monotherapy of Parkinson's disease in the early phase;

 combination therapy, together with levodopa and a decarboxylase inhibitor such as carbidopa, in progressive-phase Parkinson's disease;

 in some countries also: ablactation and dysfunctions associated with hyperprolactinemia (amenorrhea, oligomenorrhea, anovulation, nonpuerperal mastitis and galactorrhea);

 treatment of uterine fibroids.

 adjunctive therapy of acromegaly, cabergoline has low efficacy in suppressing growth hormone levels and is highly efficient in suppressing hyperprolactinemia that is present in 20-30% of acromegaly cases; growth hormone and prolactin are similar structurally and have similar effects in many target tissues, therefore targeting prolactin may help symptoms when growth hormone secretion cannot be sufficiently controlled by other methods;

 Cushing's disease

Contraindications and precautions :

 Hypersensitivity to ergot derivatives

 Pediatric patients (no clinical experience)

 Severely impaired liver function or cholestasis

 Co-medication with drugs metabolized mainly by CYP P450 such as erythromycin and ketoconazole, because increased plasma levels of cabergoline may result (although cabergoline undergoes minimal CYP450 metabolism).

 Cautions : severe cardiovascular disease, Raynaud's disease, gastroduodenal ulcers, active gastrointestinal bleeding, hypotension.

Pregnancy and lactation :

Relatively little is known about the effects of this medication during pregnancy and lactation. In some cases the related bromocriptine may be an alternative when pregnancy is expected.

 Pregnancy : available preliminary data indicates a somewhat increased rate of congenital abnormalities in patients who became pregnant while treated with cabergoline. However, one study concluded that "foetal exposure to cabergoline through early pregnancy does not induce any increase in the risk of miscarriage or foetal malformation."

 Lactation : In rats cabergoline was found in the maternal milk. Since it is not known if this effect also occurs in humans, breastfeeding is usually not recommended if/when treatment with cabergoline is necessary.

 Lactation suppression : In some countries cabergoline (Dostinex) is sometimes used as a lactation suppressant.

Drug interactions :

Some MEDICINES MAY INTERACT with this drug. Tell your health care provider if you are taking any other medicines, especially any of the following :

 Macrolides (e.g., clarithromycin) because they may increase the risk of Dostinex's side effects

 Butyrophenones (eg, haloperidol), metoclopramide, phenothiazines (eg, chlorpromazine), or thioxanthenes (e.g., thiothixene) because they may decrease Dostinex's effectiveness

 "Triptans" (eg, sumatriptan) because the risk of their side effects may be increased by this product.

Storage : Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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Martin Adam http://onlinegenericpills.com/ Vittel, Lorraine, France martinadam0122@gmail.com

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