Colorectal Neoplasms, Hereditary Nonpolyposis
- Hereditary Nonpolyposis Colorectal Cancer
- Hereditary Nonpolyposis Colorectal Neoplasms
- Lynch Syndrome
- Colon Cancer, Familial Nonpolyposis
- Lynch Cancer Family Syndrome I
- Lynch Syndrome I
Definition: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes.
http://www.hon.ch/HONselect/RareDiseases/EN/C04.588.274.476.411.307.190.html
44http://www.hon.ch/HONselect/RareDiseases/EN/C04.588.274.476.411.307.190.html
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