Pregabalin is used to treat diabetic neuropathy pain - daynighthealthcare

11 Feb 2014, Dallas, USA, (http://daynighthealthcare.com/) : Lyrica or pregabalin has been approved to treat epilepsy, diabetic neuropathy pain, and post-herpetic neuralgia (pain after shingles). In addition, pregabalin has been approved to treat fibromyalgia, a condition where there is pain in muscles and connective tissue as well as widespread pain and a heightened and painful response to touch. This drug has also approved Lyrica to treat generalized anxiety disorder.

Way of working:

Pregabalin is an oral medication that is chemically related to gabapentin (Neurontin, Gabarone). It is used for treating pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used for treating fibromyalgia. The mechanism of action of pregabalin is unknown. Pregabalin binds to calcium channels on nerves and may modify the release of neurotransmitters (chemicals that nerves use to communicate with each other). Reducing communication between nerves may contribute to pregabalin's effect on pain and seizures.

What are the side effects of Lyrica?

The most prevalent side effect of pregabalin is dizziness or drowsiness, which occurs in more than 10% of patients. Between one and ten percent of patients experience visual problems, lack of coordination in muscle movements, disorder of speech, tremor, lethargy, memory problems, euphoria, constipation, dry mouth, peripheral swelling, loss of sex drive, erectile dysfunction, and weight gain.

Less than 1 percent of patients taking pregabalin may experience depression, confusion, agitation, hallucinations, muscle twitching, change in sensitivity to touch, increased heart rate, excessive salivating, sweating, redness, rash, muscle cramps, muscle and joint pain, urinary problems, or kidney stones.

Does Lyrica interact with other drugs?

The manufacturer of Lyrica warns of potential dangerous interactions with the following drugs:

• Opioids • Benzodiazepines • Barbiturates • Alcohol • Any drugs that depress the central nervous system

DRUG INTERACTIONS: Alcohol and drugs that cause sedation may increase the sedative effects of pregabalin. Pioglitazone (Actos) androsiglitazone (Avandia) cause weight gain, fluid retention, and possibly heart failure. Therefore, combining pregabalin with these drugs may increase the occurrence of weight gain and fluid retention.

DOSING: Pregabalin may be taken with or without food. The initial dose for neuropathic pain associated with diabetic peripheral neuropathy is 50 mg three times a day (150 mg/day). The dose may be increased to a maximum dose of 100 mg 3 times daily (300 mg/day) after one week. Storage: Store at room temperature. Protect from heat, light and moisture. Keep away from reach of children.

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