Studies on animals showed deterrence of Type 1 diabetes
The current research is found to provide significant clinical implication in the field of diabetes and it regarded to be the most successful late-stage medical intervention, as most individuals are left with only few beta cells by the time they undergo diagnosis of the disease.
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August 20, 2012, USA, (Realpharmacyrx.co): As per a recent clinical intervention carried out by the researchers of the Karolinska Institute in Sweden, it has been found that they were successful in preventing the onset of Type 1 Diabetes in mice that were genetically vulnerable to acquire the disease.
It is a known fact that Type 1 Diabetes is caused due to the attack and destruction of the beta cells of the pancreas that produce insulin by the body’s own immune system. And, hence due to the destruction of the insulin producing cells, the production of insulin a downward trend and the person becomes susceptible to diabetes.
The researchers elucidated that on injecting specially prepared cells in the mice lead to the ceasing of the attack of our immune cells to the beta cells of the pancreas in the apt time and this lead the cells produce insulin normally and prevent from acquiring diabetes.
Macrophages were known to play a vital role in destruction of beta cells but, in general they act against inflammation-related damage of tissues.
The research was led by Robert Harris and his team to identify and define a novel cytokines combination, which is found to bestow protection activity on macrophages, thereby aiding in shielding the mice from acquiring Type 1 Diabetes.
The scientists used NOD (non-obese diabetic) mice, which are vulnerable to develop Type 1 Diabetes in a period of 12-30 weeks after their birth. They also grew the macrophages and activated the matured ones with specific cytokines.
The mice after 16 weeks of age were divided into three groups - namely cytokine-stimulated macrophages, inactivated macrophages and untreated (placebo) one.
The results obtained after 12 weeks showed that 25% of mice that received cytokine-stimulated macrophages developed Type 1 Diabetes, whereas around 83% mice from the other group developed the disease.
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