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HPV linked to throat cancer

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The researchers say the link between presence of E6 antibodies in the blood and oropharyngeal cancer was independent of time from blood sample to cancer diagnosis.

24th July, 2013 USA (http://www.royalpharmacyrx.com/) : One third of people with cancers in the back of the throat (oropharyngeal cancers) are infected with a certain strain of human papillomavirus (HPV), according to new research. compared pre-diagnostic blood samples from 938 patients with cancers of the head and neck, oesophageal (gullet) and oropharyngeal cancers with samples from 1,599 people without the disease (the controls).

The HPV family contains nearly 200 strains, but a very few are linked to cancer, and only one, HPV16, is firmly linked to oropharyngeal cancer. The researchers examined the blood samples for antibodies against E6, a known HPV16 cancer inducing protein, and established it in over a third of those with oropharyngeal cancers, compared with less than 1% of the cancer-free controls.

If a person has antibodies to E6, then they are contaminated with HPV16, and there is a high risk that the cancer-causing process that E6 triggers has been activated.E6 switches off another protein called p53 that protects cells from DNA damage. Damage to DNA increases the danger of cancer development, and that is why p53 is often known as the "guardian of the genome".

The researchers say the link between presence of E6 antibodies in the blood and oropharyngeal cancer was independent of time from blood sample to cancer diagnosis. These striking results provide some evidence that HPV16 infection may be a significant cause of oropharyngeal cancer."

HPV16 is a major cause of cervical cancer (with HPV18), and it spreads through genital or oral contact. It also raises the risk for vulval, penile and anal cancers.

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HPV linked to throat cancer The researchers say the link between presence of E6 antibodies in the blood and oropharyngeal cancer was independent of time from blood sample to cancer diagnosis.

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