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By detecting DNA mutations treatment for cancer, tuberculosis can be improved

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By detecting DNA mutations treatment for cancer, tuberculosis can be improved

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DNA is a type of nucleic acid, the biological molecule that gives all living things their sole genetic signatures.

2nd August 2013, UK (http://www.kamagramart.com) : The least mutation in a sequence of DNA can have sound effects. The study has shown that just one mutation can be the difference between successfully treating a disease and having it spread uncontrollably throughout the body.

The researchers have discovered a new method that can look at a peculiar segment of DNA and pinpoint a single mutation, which could succor diagnose and treat diseases such as cancer and tuberculosis. These minute changes can be the root of a disease or the reason some infectious diseases withstand definite antibiotics.

DNA is a type of nucleic acid, the biological molecule that gives all living things their sole genetic signatures. In a double strand of DNA, that is also known as a double helix, a series of base pairs, bond and cipher our genetic information. It's clear that a change of just one base pair - a sequence mutation, an insertion or a deletion - is enough to trigger major biological consequences. This could import the onset of disease, or the reason some diseases don't react to usual antibiotic treatment.

The designed probes that can pick out mutations in a single base pair in a target stretch of DNA. The probes permit researchers to look in much more detail for variations in long sequences - up to 200 base pairs while current methods can detect mutations in stretches of up to only 20.

The testing probes are designed to bind with a sequence of DNA that is believed of having a mutation. The researchers do this by generating a complimentary sequence of DNA to the double-helix strand in question. Then, they admit molecules containing both sequences to mix in a test tube in salt water, where they certainly will match up to one another if the base pairs are intact. The probe molecule checks both strands of the target double helix for mutations rather than just one, which signifies the increased specificity.

The probe is engineered to emit a fluorescent glow if there's a perfect match between it and the target. If it doesn't lighten, that means the strands didn't match and there was in fact a mutation in the target strand of DNA.

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Kamagramart

Marylebone High Street,

London,

City of London,

UNITED KINGDOM,

EC2P 2EJ.
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By detecting DNA mutations treatment for cancer, tuberculosis can be improved
 DNA is a type of nucleic acid, the biological molecule that gives all living things their sole genetic signatures.

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