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Breast cancer drugs may be utilized to treat lung cancer

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Breast cancer drugs may be utilized to treat lung cancer

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The inhibitors work by aiming two DNA repair systems at the same time, killing cancer cells while evading the healthy cells.

16th August 2013 , UK (http://www.kamagramart.com/) : According to a study, scientists have discovered that experimental drugs developed as treatments of ovarian and breast cancer could be used to treat lung cancer. The researchers have revealed that drugs called PARP (poly ADP ribose polymerase) inhibitors could help treat around 50% of non-small-cell lung cancer (NSCLC) tumors.

PARP inhibitors are already used as a treatment for women suffering from breast or ovarian cancer caused by faulty BRCA1 or BRCA2 genes. The inhibitors work by aiming two DNA repair systems at the same time, killing cancer cells while evading the healthy cells.

They explain that half of NSCLC tumors have a fault that blocks one of the ways cells repair errors in DNA. The defect is in a key protein involved in DNA repair called Excision Repair Cross-Complementation group 1 (ERCC1).

Using PARP inhibitors for NSCLC could work by damaging another DNA damage repair system, the researchers say. This could induce secondary damage and kill lung cancer cells, while evading harm to healthy tissue. Lung cancer is hard to treat and unfortunately has very poor survival, so there is an instant need to find new treatments. The research opens up an exciting new route, by demonstrating how we could repurpose drugs primarily designed for use against other forms of cancer.

Around 85-90% of lung cancers are non-small cell lung cancers, and it is the second most normal cancer in both men and women worldwide. Survival rates of NSCLC remain low. At phase one of the cancer, when it has not yet spread to the lymph nodes or other organs, there is an evaluated five-year survival rate of 49%. Lung cancer is proven to be one of the hardest cancers to study and survival rates remain poor.

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Breast cancer drugs may be utilized to treat lung cancer The inhibitors work by aiming two DNA repair systems at the same time, killing cancer cells while evading the healthy cells.

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